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| Apoptosis: Mechanisms and Role in Disease |
 | Author(s): Kumar, S., (Ed.):
ISBN: 3-540-64624-8
Publisher:
Price: $167.79
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| Summary: This volume deals with many of the recent advances made in uncovering the molecular and cellular basis of apoptosis and elaborates on how this accumulating knowledge is helping us to understand the significance of apoptosis in pathogenesis of diseases arising from inappropriate cell death. Further, mechanistic aspects of cell death and role of apoptosis in disease is covered. |
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| Biology of Aging |
 | Author(s): Macieira-Coelho, A., (Ed.)
ISBN: 3-540-43827-0
Publisher:
Price: $111.84
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| Summary: This volume gives the reader a comprehensive overview of the fundamental and biological aspects of aging. First, the field is described from a historical perspective. Then, the author analyzes the three fundamental mechanisms of survival: energy utilization, molecular and cellular redundancy, and the organization of information. The genetics of aging is reviewed rejecting some simple-minded interpretations. A bridge is established between the molecular, cellular, and tissue modifications that have been reported in the literature, and the clinical manifestations of the aging syndrome. Special relevance is given to the problem of the supposed association between cancers and aging, giving a new interpretation of that relationship. |
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| Cell Immortalization |
 | Author(s): Macieira-Coelho, A., (Ed.):
ISBN: 3-540-65618-9
Publisher:
Price: $167.79
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| Summary: This book describes the most outstanding theoretical hypotheses aiming at explaining the infinite proliferative potential of a cell population, what is now known under the term cell immortalization. It elucidates the phenomenon from an evolutionary point of view, and describes the cell systems used and the experiments performed at the cellular and molecular levels to determine the mechanisms responsible for this cell property. It also appraises how the mortal and immortal phenotypes reflect characteristics of the respective organism, and stresses how this goes beyond the proposal that its opposite, the mortal phenotype, is a mechanism to protect the organism against cancer. |
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| Inhibitors of Cell Growth |
 | Author(s): Macieira-Coelho, A., (Ed.):
ISBN: 3-540-64092-4
Publisher:
Price: $167.79
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| Summary: The study of the control of cell growth is of particular importance for the understanding of cancer and various developmental abnormalities. This book considers both internal and external regulators of cell division, and addresses therapeutic applications and structure-function relationships. This book will be of interest to both cell biologists and biomedical researchers. |
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| Signaling Through the Cell Matrix |
| | Author(s): Macieira-Coelho, A., (Ed.):
ISBN: 3-540-67220-6
Publisher:
Price: $95.06
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| Summary: This book covers a hot subject in cell biology; i.e. how the cell environment sends messages to the cell, regulates gene expression, and modulates the cell phenotype. For a long time the extracellular matrix was believed to have only a supporting role for cell attachment. However, it became apparent that the matrix participates actively in cell metabolism. The experiments that led to this conclusion are described in this volume. Progressively, molecules have been identified that transmit this signaling at the cell-matrix interface. Their identity and mechanism of action are also illustrated in this book. Finally, it explains the role the cell-matrix relationship plays in the regulation of cell proliferation, cell differentiation, and the expression of malignancy. |
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