Summary: Since the first successful transfer of an in vitro fertilised human egg in 1976, modern endocrinology, genetics, and assisted reproductive technologies have opened new frontiers of research with the aim to treat infertile women. In this workshop we set out to promote an interdisciplinary discussion between experts from various fields of basic, company-based and clinical research related to folliculogenesis and oocyte development. The aim of this workshop was to present, discuss and assess novel approaches in mammalian folliculogenesis and oocyte development that may have an impact on fertility/ infertility in the near or distant future. Key issues were the understanding of new modulators of folliculogenesis and regulators of cytoplasmic as well as meiotic oocyte maturation, modern technologies, the aging oocyte and pathogenetic mechanisms of infertility.
Author(s): Evans, C. H.; Robbins, P. D., (Eds.): ISBN: 3-7643-5855-6 Publisher:
Price: $163.37
Summary: Gene therapy for inflammatory diseases is a new , burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren`s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included.
Author(s): Fernandes, J.; Saudubray, J.-M.; Berghe, G. van den, (Eds.): ISBN: 3-540-65626-X Publisher:
Price: $134.22
Summary: The diagnosis and treatment of metabolic diseases represent the main issues of this clinical book. Each disease-related chapter starts with a figure which presents an outline of the metabolic pathway, the locations of its inborn defects, and a short explanation of its major functions. The position of the figure on the left-hand page facilitates its consultation when reading further. The text begins with a short clinical abstract and discusses clinical presentation, metabolic derangement, diagnosis, treatment and prognosis, genetics and references for each disease. Five chapters on the general principles of diagnosis and treatment precede the chapters on specific disorders. The first and most important one is an introduction to the clinical approach to inborn metabolic disease. The others deal with diagnostic procedures, emergency treatments, psychosocial care, and the present status of treatments, with comprehensive lists and new trends of treatment.
Summary: Contradictory results in schizophrenia research are generally explained as being due to genetic heterogeneity and multiple factor heredity in relationship to manifold environmental factors. The book reports a short overview of all relevant twin studies on schizophrenic psychoses and provides data and case histories on a systematic twin study based on a polydiagnostic approach carried out by two independently working psychiatrists. In addition to the internationally applied operational diagnostic systems of DSM-III-R and ICD 10, Leonhard's subclassification of schizophrenic psychoses was used. Up to now this sophisticated methodological approach is unique in the world. The data provide strong evidence that the spectrum of psychoses with schizophrenic and schizophrenia-like symptoms is not a continuum of diseases. At least in Leonhard's three major groups of cycloid psychoses, unsystematic schizophrenias and systematic schizophrenias genetic, somatic and psycho-social factors play a completely different etiological role. Cycloid psychoses and systematic schizophrenias are predominantly caused by "environmental" factors. In unsystematic schizophrenias, however, genetic predisposition is the main etiological factor and environmental factors are subordinate.
